解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Foraminiferan protists, which are significant players in most marine ecosystems, are also genetic innovators, harboring unique modifications to proteins that make up the basic eukaryotic cell machinery. Despite their ecological and evolutionary importance, foraminiferan genomes are poorly understood due to t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-169
更新日期:2011-03-31 00:00:00
abstract:BACKGROUND:The transcription factors peroxisome proliferator activated receptor γ (PPARγ) and CCAAT/enhancer binding protein α (C/EBPα) are key transcriptional regulators of adipocyte differentiation and function. We and others have previously shown that binding sites of these two transcription factors show a high degr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-152
更新日期:2011-03-16 00:00:00
abstract:BACKGROUND:Crustacean moulting is a complex process involving many regulatory pathways. A holistic approach to examine differential gene expression profiles of transcripts relevant to the moulting process, across all moult cycle stages, was used in this study. Custom cDNA microarrays were constructed for Portunus pelag...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-147
更新日期:2011-03-12 00:00:00
abstract:BACKGROUND:MicroRNAs (miRNAs) are post-transcriptional regulators of mRNA expression and are involved in numerous cellular processes. Consequently, miRNAs are an important component of gene regulatory networks and an improved understanding of miRNAs will further our knowledge of these networks. There is a many-to-many ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-138
更新日期:2011-03-06 00:00:00
abstract:BACKGROUND:Tea is one of the most popular non-alcoholic beverages worldwide. However, the tea plant, Camellia sinensis, is difficult to culture in vitro, to transform, and has a large genome, rendering little genomic information available. Recent advances in large-scale RNA sequencing (RNA-seq) provide a fast, cost-eff...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-131
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:The Chinese Taihu is one of the most prolific pig breeds in the world, which farrows at least five more piglets per litter than Western pig breeds partly due to a greater ovulation rate. Variation of ovulation rate maybe associated with the differences in the transcriptome of Chinese Taihu and Large White ov...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-111
更新日期:2011-02-16 00:00:00
abstract:BACKGROUND:DNA microarray technology has had a great impact on muscle research and microarray gene expression data has been widely used to identify gene signatures characteristic of the studied conditions. With the rapid accumulation of muscle microarray data, it is of great interest to understand how to compare and co...
journal_title:BMC genomics
pub_type: 杂志文章,meta分析
doi:10.1186/1471-2164-12-113
更新日期:2011-02-16 00:00:00
abstract:BACKGROUND:Nucleosome positioning has an important role in gene regulation. However, dynamic positioning in vivo casts doubt on the reliability of predictions based on DNA sequence characteristics. What role does sequence-dependent positioning play? In this paper, using a curvature profile model, nucleosomes are predic...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-72
更新日期:2011-01-27 00:00:00
abstract:BACKGROUND:Although primarily known as the site of ribosome subunit production, the nucleolus is involved in numerous and diverse cellular processes. Recent large-scale proteomics projects have identified thousands of human proteins that associate with the nucleolus. However, in most cases, we know neither the fraction...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-74
更新日期:2011-01-27 00:00:00
abstract:BACKGROUND:After several years in the juvenile phase, trees undergo flowering transition to become mature (florally competent) trees. This transition depends on the balanced expression of a complex network of genes that is regulated by both endogenous and environmental factors. However, relatively little is known about...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-63
更新日期:2011-01-26 00:00:00
abstract:BACKGROUND:One member of the W family of human endogenous retroviruses (HERV) appears to have been functionally adopted by the human host. Nevertheless, a highly diversified and regulated transcription from a range of HERV-W elements has been observed in human tissues and cells. Aberrant expression of members of this f...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-22
更新日期:2011-01-12 00:00:00
abstract:BACKGROUND:Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency. These levels in rats increase sigmoidally with increasing dietary Se and reach defined plateaus at the Se requirement, making them sensitive biomarkers for...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-26
更新日期:2011-01-12 00:00:00
abstract:BACKGROUND:Gaucher disease is caused by defective glucocerebrosidase activity and the consequent accumulation of glucosylceramide. The pathogenic pathways resulting from lipid laden macrophages (Gaucher cells) in visceral organs and their abnormal functions are obscure. RESULTS:To elucidate this pathogenic pathway, de...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-20
更新日期:2011-01-11 00:00:00
abstract:BACKGROUND:There is a large amount of inconsistency in gene structure annotations of bacterial strains. This inconsistency is a frustrating impedance to effective comparative genomic analysis of bacterial strains in promising applications such as gaining insights into bacterial drug resistance. RESULTS:Here, we propos...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-S2-S6
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:The tuberous root of sweet potato is an important agricultural and biological organ. There are not sufficient transcriptomic and genomic data in public databases for understanding of the molecular mechanism underlying the tuberous root formation and development. Thus, high throughput transcriptome sequencing...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-726
更新日期:2010-12-24 00:00:00
abstract:BACKGROUND:Alternative splicing (AS) is a central mechanism in the generation of genomic complexity and is a major contributor to transcriptome and proteome diversity. Alterations of the splicing process can lead to deregulation of crucial cellular processes and have been associated with a large spectrum of human disea...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S5-S4
更新日期:2010-12-22 00:00:00
abstract:BACKGROUND:Two-component systems (TCSs) are modular and diverse signalling pathways, involving a stimulus-responsive transfer of phosphoryl groups from transmitter to partner receiver domains. TCS gene and domain organisation are both potentially informative regarding biological function, interaction partnerships and m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-720
更新日期:2010-12-20 00:00:00
abstract:BACKGROUND:Parasitic wasps constitute one of the largest group of venomous animals. Although some physiological effects of their venoms are well documented, relatively little is known at the molecular level on the protein composition of these secretions. To identify the majority of the venom proteins of the endoparasit...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-693
更新日期:2010-12-07 00:00:00
abstract:BACKGROUND:Developing effective strategies to reveal modular structures in protein interaction networks is crucial for better understanding of molecular mechanisms of underlying biological processes. In this paper, we propose a new density-based algorithm (ADHOC) for clustering vertices of a protein interaction network...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S4-S17
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:The increasing numbers of 3D compounds and protein complexes stored in databases contribute greatly to current advances in biotechnology, being employed in several pharmaceutical and industrial applications. However, screening and retrieving appropriate candidates as well as handling false positives presents...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S4-S26
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:The orphan nuclear receptor TR4 (human testicular receptor 4 or NR2C2) plays a pivotal role in a variety of biological and metabolic processes. With no known ligand and few known target genes, the mode of TR4 function was unclear. RESULTS:We report the first genome-wide identification and characterization o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-689
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:Microarray technology is limited to monitoring the expression of previously annotated genes that have corresponding probes on the array. Computationally annotated genes have not fully been validated, because ESTs and full-length cDNAs cannot cover entire transcribed regions. Here, mRNA-Seq (an Illumina cDNA ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-683
更新日期:2010-12-02 00:00:00
abstract:BACKGROUND:The increasing resistance of Plasmodium, the malaria parasites, to multiple commonly used drugs has underscored the urgent need to develop effective antimalarial drugs and vaccines. The new direction of genomics-driven target discovery has become possible with the completion of parasite genome sequencing, wh...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S3-S13
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:The identification and quantification of proteins using label-free Liquid Chromatography/Mass Spectrometry (LC/MS) play crucial roles in biological and biomedical research. Increasing evidence has shown that biomarkers are often low abundance proteins. However, LC/MS systems are subject to considerable noise...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S3-S8
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Whilst being closely related to the model actinomycete Streptomyces coelicolor A3(2), S. lividans 66 differs from it in several significant and phenotypically observable ways, including antibiotic production. Previous comparative gene hybridization studies investigating such differences have used low-density...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-682
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Succinate is produced petrochemically from maleic anhydride to satisfy a small specialty chemical market. If succinate could be produced fermentatively at a price competitive with that of maleic anhydride, though, it could replace maleic anhydride as the precursor of many bulk chemicals, transforming a multi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-680
更新日期:2010-11-30 00:00:00
abstract:BACKGROUND:Genetic populations provide the basis for a wide range of genetic and genomic studies and have been widely used in genetic mapping, gene discovery and genomics-assisted breeding. Chromosome segment substitution lines (CSSLs) are the most powerful tools for the detection and precise mapping of quantitative tr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-656
更新日期:2010-11-24 00:00:00
abstract:BACKGROUND:Genomic imprinting is an evolutionary conserved mechanism of epigenetic gene regulation in placental mammals that results in silencing of one of the parental alleles. In order to decipher interactions between allele-specific DNA methylation of imprinted genes and evolutionary conservation, we performed a gen...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-649
更新日期:2010-11-22 00:00:00
abstract:BACKGROUND:Macrosatellites are some of the largest variable number tandem repeats in the human genome, but what role these unusual sequences perform is unknown. Their importance to human health is clearly demonstrated by the 4q35 macrosatellite D4Z4 that is associated with the onset of the muscle degenerative disease f...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-632
更新日期:2010-11-15 00:00:00
abstract:BACKGROUND:Comparative genomics has emerged as a promising means of unravelling the molecular networks underlying complex traits such as drought tolerance. Here we assess the genotype-dependent component of the drought-induced transcriptome response in two poplar genotypes differing in drought tolerance. Drought-induce...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-630
更新日期:2010-11-12 00:00:00
abstract:BACKGROUND:Regulation of bacterial gene expression by small RNAs (sRNAs) have proved to be important for many biological processes. Francisella tularensis is a highly pathogenic Gram-negative bacterium that causes the disease tularaemia in humans and animals. Relatively little is known about the regulatory networks exi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-625
更新日期:2010-11-10 00:00:00
abstract:BACKGROUND:In many microbial genomes, a strong preference for a small number of codons can be observed in genes whose products are needed by the cell in large quantities. This codon usage bias (CUB) improves translational accuracy and speed and is one of several factors optimizing cell growth. Whereas CUB and the overr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-617
更新日期:2010-11-04 00:00:00
abstract:BACKGROUND:Starches are the main storage polysaccharides in plants and are distributed widely throughout plants including seeds, roots, tubers, leaves, stems and so on. Currently, microscopic observation is one of the most important ways to investigate and analyze the structure of starches. The position, shape, and siz...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S2-S13
更新日期:2010-11-02 00:00:00
abstract:BACKGROUND:Ultrasound imaging technology has wide applications in cattle reproduction and has been used to monitor individual follicles and determine the patterns of follicular development. However, the speckles in ultrasound images affect the post-processing, such as follicle segmentation and finally affect the measur...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-S2-S9
更新日期:2010-11-02 00:00:00
abstract:BACKGROUND:Adenosine to inosine (A-to-I) RNA-editing is an essential post-transcriptional mechanism that occurs in numerous sites in the human transcriptome, mainly within Alu repeats. It has been shown to have consistent levels of editing across individuals in a few targets in the human brain and altered in several hu...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-608
更新日期:2010-10-28 00:00:00
abstract:BACKGROUND:The Multinational Brassica rapa Genome Sequencing Project (BrGSP) has developed valuable genomic resources, including BAC libraries, BAC-end sequences, genetic and physical maps, and seed BAC sequences for Brassica rapa. An integrated linkage map between the amphidiploid B. napus and diploid B. rapa will fac...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-594
更新日期:2010-10-22 00:00:00
abstract:BACKGROUND:Roche 454 pyrosequencing has become a method of choice for generating transcriptome data from non-model organisms. Once the tens to hundreds of thousands of short (250-450 base) reads have been produced, it is important to correctly assemble these to estimate the sequence of all the transcripts. Most transcr...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-571
更新日期:2010-10-16 00:00:00
abstract:BACKGROUND:Cucumber, Cucumis sativus L. is an important vegetable crop worldwide. Until very recently, cucumber genetic and genomic resources, especially molecular markers, have been very limited, impeding progress of cucumber breeding efforts. Microsatellites are short tandemly repeated DNA sequences, which are freque...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-569
更新日期:2010-10-15 00:00:00
abstract:BACKGROUND:Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabol...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-555
更新日期:2010-10-11 00:00:00
abstract:BACKGROUND:Neighboring gene pairs in the genome of Saccharomyces cerevisiae have a tendency to be expressed at the same time. The distribution of histone modifications along chromatin fibers is suggested to be an important mechanism responsible for such coexpression. However, the extent of the contribution of histone m...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-550
更新日期:2010-10-09 00:00:00